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A novel neural interfacing electrode array for electrical stimulation and simultaneous recording of EEG/EMG/ENGOpen Access
Abstract: Neural interface is man-made information pathway through which biological nerve system could communicate directly with electromechanical devices including computer, robot and even cyborg. This paper introduces a novel neural interfacing electrode array capable of bidirectional information transmission and multi-signals recording. The novel flexible electrode array with 32 channels enables close-looped control and feedback neural interfacing researches with the capability of both electrical stimulation and simultaneous recording of electroencephalogram (EEG), electromyogram (EMG), electroneurogram (ENG) signals. The electrochemical impedance spectroscopy (EIS) measurement of the electrode array was carried out to evaluate the electrode array electrochemical performance in the electrophysiology frequency range. Electrical stimulation to peripheral nerve was performed with various stimulation configuration of ENG electrode site pairs to produce distinct activation patterns. Muscle action potentials of the gastrocnemius of the hind limb indicated different configuration of electrode site pairs could generate distinct stimulating effect. In addition, three groups of in vivo experiments were conducted to demonstrate the recording ability of the electrode array for nerve signals. The data from 32 channels verified the effectiveness of this flexible electrode array in simultaneous recording of EEG/EMG/ENG in vivo.
Construction of a focused ultrasound neuromodulation system for the treatment of epileptic seizureOpen Access
Abstract: Thus far, Ultrasound has been proved to be useful for noninvasively stimulating brain activity and has hope to play a positive role in the treatment of neurological diseases. Epilepsy is a neurological disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, and sometimes loss of awareness. In this paper, we established a focused ultrasound (FUS) neuromodulation system for the treatment of epilepsy. We used the chemically-induced rat epilepsy model to explore the effect of pulsed focused ultrasound on epilepsy, and obtained preliminary experimental results. We have proved the feasibility of this system through experiments, which can be used in the treatment of epilepsy by ultrasound neuromodulation.